Web5 apr. 2024 · (RTTNews) - Ionis Pharmaceuticals, Inc. (IONS) has begun the late-stage study of its investigational drug, ION363 in patients with amyotrophic lateral sclerosis (ALS),the company said in a... Web9 apr. 2024 · According to a press release from April 8, 2024, a partnership between Project ALS and the ALS Association has allowed for the development of a Phase 3 clinical trial. …
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WebION363 is an antisense oligonucleotide designed to reduce the production of a mutated, neurotoxic form of the Fused in Sarcoma (FUS) protein. FUS mutations have been … Web30 apr. 2000 · This paper will familiarize the reader with the terms used to describe the behavior of ion-selective electrodes, particularly in relation to their use in clinical chemistry for determination of blood electrolyte cations. It serves as an introduction to a series of papers dealing with important cations in blood, namely calcium, sodium, and potassium. … Web1 jul. 2024 · Electrospray ionization in the positive ion mode was applied for detection of cortisol (precursor>product ion: 363.3>121.0), cortisol-d4 (internal standard, IS, 367.4>121.1), and cortisone (361.2>163.2). To maximize ionization, acetic acid-ammonium acetate buffer (18mM) at pH 5.3 was employed as eluent A. cis electrode handling